Nature July 2022

This research article outlines key findings from the GenOMICC study, using whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose patients to critical COVID-19. This included novel 16 variants which were yet to be identified. The multiple variants found in this study tended to be involved in the two mechanisms which have been proposed as the major drivers of severe disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. This article determines the use of the GenOMMIC study in comparing cases of critical illness against population controls in the highly efficient detection of therapeutically relevant mechanisms of disease.